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KMID : 0812020040100010057
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Korean Journal of Neurogastroenterology and Motility
2004 Volume.10 No. 1 p.57 ~ p.62
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Mucosal Mast Cells in Irritable Bowel Syndrome
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Choi Jae-Hong
Nah Byung-Kyu
Lim Jung-Muk
Bae Sang-Seok
Choi Ki-Won
Chae Hee-Bok
Park Seon-Mee
Youn Sei-Jin
Sung Ro-Hyun
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Abstract
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Backgr ound/Aims: Irritable bowel syndrome (IBS) is ubiquitous but the pathophysiology remains poorly established. There has been increasing interest in the role of mast cells (MC) as they release variable mediators and have receptors for neurotransmitters. The aim of this study was to determine whether MC were increased in the colonic mucosa of IBS patients compared to controls.
Methods: Biopsy was done from the cecum, ascending colon, descending colon and rectum of 29 patients: 16 IBS, 8 normal, and 5 inflammatory controls. Tissue was stained immunohistochemically with a monoclonal antibody for human mast cell tryptase for MC, and H&E stain for other inflammatory cells.
Results: MC count of IBS patients at the descending colon (15.2±4.0) was significantly higher than that of either normal controls (10.9±2.7) or inflammatory controls (11.0±2.9). In a group of patients with IBS, MC count at the cecum was significantly higher in the constipation-predominant subtype (21.3±3.4) and the pain-predominant subtype (22.7±2.5) than the diarrheapredominant subtype (14.7±4.2).
Conclusions: Patients with IBS have higher MC count than controls, and MC count in constipation-predominant IBS patients was significantly higher than diarrhea-predominant IBS patients. These findings suggest that MC might play an important role in IBS. (Kor J Neur ogastr oenter ol Motil 2004;1:57-62)
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KEYWORD
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Irritable bowel syndrome, Colon, Mast cell, Inflammatory cell,
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